Turkish Journal of Urology
Original Article

Paraoxonase and arylesterase activity in bladder cancer

1.

Department of Urology, Dicle University School of Medicine, Diyarbakır, Turkey

2.

Department of Urology, Harran University School of Medicine, Şanlıurfa, Turkey

3.

Department of Urology, Ministry of Health, Antalya Training and Research Hospital, Antalya, Turkey

4.

Department of Urology, Ministry of Health, Adana Numune Training and Research Hospital, Adana, Turkey

Turk J Urol 2017; 43: 147-151
DOI: 10.5152/tud.2017.89411
Read: 542 Downloads: 242 Published: 25 July 2019

Abstract

Objective: Oxidative stress is the main pathogenetic mechanism in bladder cancer among many other causes. We aimed to investigate whether a potential relationship exists between bladder cancer and the activities of paraoxonase (PON1) and arylesterase (ARE) enzymes.

 

Material and methods: The study included 56 patients with bladder cancer, and 57 healthy individuals. The relationships between enzyme activity and tumour grade, stage, muscular invasion and tumour size were evaluated. For statistical analysis, One-Sample Kolmogorov-Smirnov, Independent-T, ANOVA and Post-Hoc Bonferroni tests were used.

 

Results: Serum levels of PON1 and ARE enzymes, and total cholesterol were significantly lower in bladder cancer group. While other lipid parameters were similar in both the patient and the control groups. Levels of ARE were positively correlated with lipid parameters except for HDL cholesterol.

 

Conclusion: Our results showed that decreased serum PON1 and ARE enzyme activities are related with tumour load and recurrence. Further studies with larger samples are needed to confirm predictive role of enzymatic activities of PON1 and ARE in the diagnosis and prognosis of bladder cancer.

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EISSN 2149-3057