Turkish Journal of Urology
GENERAL UROLOGY - Original Article

The effect of tramadol on oxidative stress total antioxidant levels in rats with renal ischemia-reperfusion injury

1.

Department of Anesthesiology and Reanimation, Gaziantep University Faculty of Medicine, Gaziantep, Turkey

2.

Department of Physiology, Gaziantep University Faculty of Medicine, Gaziantep, Turkey

3.

Department of Pathology, Gaziantep University Faculty of Medicine, Gaziantep, Turkey

4.

Department of Biochemistry, Gaziantep University Faculty of Medicine, Gaziantep, Turkey

5.

Department of Urology, Gaziantep University Faculty of Medicine, Gaziantep, Turkey

Turk J Urol 2020; 46: 388-392
DOI: 10.5152/tud.2020.20227
Read: 143 Downloads: 64 Published: 31 August 2020

Objective: To evaluate the protective effect of tramadol on renal tissue in rats with induced renal ischemia-reperfusion injury (I/R injury), and its effects on oxidative stress.

Material and methods: Thirty adult, male Wistar rats weighing 250–300 g were selected as subjects. Rats were randomized into 3 groups: group 1, sham; group 2, renal I/R injury; and group 3, renal I/R+Tramadol. In order to obtain ischemia in groups 2 and 3, renal artery was clamped for 1 h. Total oxidant status (TOS) and total antioxidant capacity (TAC) were analyzed using biochemical assays in the serum samples.

Results: TOS values were measured as 1.68±0.4 in group 1, 3.35±1.0 in group 2, and 3.49±0.9 in group 3. When group 1 was compared with group 2 and group 3, the TOS values of group 1 were significantly lower (p<0.05), whereas there was no difference between group 2 and group 3 (p>0.05). TAC values were measured as 1.65±1.4 in group 1, 1.85±0.1 in group 2, and 2.79±0.6 in group 3. The antioxidant status of group 1 was not significantly different from that of group 2 (p>0.05), whereas there was a significant difference between group 1 and group 3 (p>0.05).

Conclusions: Tramadol has positive effects on antioxidant levels in renal I/R injury. We think that tramadol may be used in patients who underwent renal surgery and have I/R injury risk. There is a need for studies on this subject including human series.

Cite this article as: Şen E, Kaplan DS, Bozdağ Z, Örkmez M, Mızrak A, Şen H, et al. The effect of tramadol on oxidative stress total antioxidant levels in rats with renal ischemia-reperfusion injury. Turk J Urol 2020; 46(5): 388-92.

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ISSN2149-3235 EISSN 2149-3057