Turkish Journal of Urology
UROONCOLOGY - Original Article

Evaluation of germ-cell neoplasia in situ entity in testicular tumors


Department of Urology, Health Sciences University Haydarpaşa Numune Training and Research Hospital, İstanbul, Turkey

Turk J Urol 2019; 45: 418-422
DOI: 10.5152/tud.2018.48855
Read: 841 Downloads: 387 Published: 11 October 2019

Objective: Germ-cell neoplasia in situ (GCNIS) is accepted as the precursor of the testicular tumors. The aim in our study is to compare the lymphadenopathy and metastasis parameters in patients diagnosed with testicular tumor with or without GCNIS based on pathological evaluation.

Material and methods: Data from 108 patients who underwent orchiectomy for testicular tumor between January 2007 and December 2014 in our clinic were retrospectively analyzed and included in the study. Patients were divided into two groups based on the pathology reports as GCNIS or not. Groups were compared regarding lymphadenopathy, metastasis, tumor marker levels, tumor size, lymphovascular invasion, rete testis invasion. Mann-Whitney U test was used for statistical evaluation.

Results: Mean age of the patients included in the study were calculated as 34.6±9.3 years. Eighty-five (78.7%) patients had GCNIS, while 23 (21.3%) of them had not. In terms of metastasis, lymphadenopathy, marker levels, tumor size, lymphovascular invasion and rete testis invasion, no statistical significant difference were observed between two groups (p>0.05).

Conclusion: In our study, no statistical significant difference was observed on the prognostic factors concerning the GCNIS entity, which is reported frequently in testicular tumor pathologies. For presently these findings show us that GCNIS cannot be used as a prognostic factor.


Cite this article as: Akyüz M, Topaktaş R, Ürkmez A, Koca O, Öztürk Mİ. Evaluation of germ-cell neoplasia in situ entity in testicular tumors. Turk J Urol 2019; 45(6): 418-22.

ISSN2149-3235 EISSN 2149-3057