Turkish Journal of Urology
Original Article

Effect of low-energy shockwave therapy on angiogenic factors in the penile tissue of diabetic rats


Department of Urology, İstanbul University İstanbul School of Medicine, İstanbul, Turkey


Department of Biochemistry, İstanbul University İstanbul School of Medicine, İstanbul, Turkey

Turk J Urol 2017; 43: 130-134
DOI: 10.5152/tud.2017.35002
Read: 724 Downloads: 433 Published: 25 July 2019


Objective: The aim of this study is to investigate the effect of low-energy shock wave therapy (LESWT) on angiogenesis factors at penile tissue in a diabetic rat model.


Material and methods: A total of 30 male Sprague-Dawley rats which were allocated into three equal groups were included study. Group 1 (control group) included 10 male rats which did not receive any treatment were randomly chosen to serve as normal control. The remaining rats were injected intraperitoneally with 60 mg/kg of streptozotocin (STZ) to induce diabetes. Diabetic rats were divided into two equal group which constituted diabetic control, and LESWT treatment (DM+LESWT) group. Each rat in the DM+LESWT group received L-ESWT therapy. Endothelial nitric oxide synthase (eNOS) and vascular endothelial growth factor (VEGF) mRNA expression levels of penile tissue were evaluated.


Results: Following STZ dosing eNOS level dropped in the diabetic control group relative to the control group. Statistically significant increase in eNOS levels were seen in the LESWT+DM group. Similarly, in the diabetic control group STZ treatment decreased VEGF levels, while in the LESWT+DM group VEGF nearly approached to baseline levels. However variations in VEGF levels were not statistically significant.


Conclusion: Mechanism action of ESWT in the penile tissue seems to involve angiogenic factors.

EISSN 2149-3057