Turkish Journal of Urology
Case Report

Carcinosarcoma/sarcomatoid carcinoma of the urinary bladder with features of malignant fibrous histiocytoma: the role of p53 in growth of the tumor

1.

Ankara University Faculty of Medicine, Department of Pathology, Ankara, Turkey

2.

Ankara University Faculty of Medicine, Department of Urology, Ankara, Turkey

Turk J Urol 2011; 37: 172-176
Read: 307 Downloads: 131 Published: 25 July 2019

Abstract

This is a report of a case of carcinosarcoma/sarcomatoid carcinoma (CS/SC) of the urinary bladder. The patient underwent multiple excisional biopsies of the urinary bladder. Following development of multiple lung metastases, the patient died at 21 months after diagnosis. This case represents a very rare example of CS/SC of the urinary bladder with a malignant fibrous histiocytoma component that was characterized by morphologic and immunohistochemical findings, and proves that CS/SC of the urinary bladder is a very aggressive neoplasm. Analysis of the tumor indicated that different factors other than p53 may be associated with the growth of this tumor. 

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ISSN2149-3235 EISSN 2149-3057