ISSN 2149-3235 | E-ISSN 2149-3057
Original Article
The effect of coenzyme Q and selenium on kidney in rats with partial unilateral ureteral obstruction
1 Department of Urology, Kırıkkale University School of Medicine, Kırıkkale, Turkey  
2 Department of Biochemistry, Kırıkkale University School of Medicine, Kırıkkale, Turkey  
3 Department of Pathology, Kırıkkale University School of Medicine, Kırıkkale, Turkey  
Turk J Urol ; : -
DOI: 10.5152/tud.2018.22556
Key Words: Coenzyme Q; kidney; oxidative stress index; paraoxonase; partial unilateral ureteral obstruction; selenium; total antioxidant capacity; total oxidant status
Abstract

Objective: In this study, we aimed to investigate the antioxidant effects of selenium and coenzyme Q on renal damage in a partial unilateral ureteral obstruction (PUUO) in a rat model.


Material and methods
:  A total of 24 Sprague-Dawley rats were divided into four groups as Group 1 Control Group, Group 2, PUUO Group, Group 3 PUUO + coenzyme Q group, Group 4 PUUO + selenium group. Paraoxonase (PON), total antioxidant capacity (TAC), and total oxidant levels (TOS) were analyzed biochemically from tissue and blood samples. Tissue samples were examined histopathologically.


Results
: The TAC in the tissues was found to be statistically significantly increased in Groups 3 and 4, compared to Group 2. Tissue TOS was found to be significantly reduced in Groups 3 and 4, compared to Group 2. Serum PON levels were significantly increased in Group 3 and 4, compared to Group 1 and 2. Histopathological examination showed that interstitial inflammation and congestion were lesser in the coenzyme Q and selenium groups than in the PUUO group. A more significant decrease was found in the selenium group than in the coenzyme Q group.


Conclusion
: Our study results showed that coenzyme Q and selenium reduced the oxidation and the damage in tissue in PUUO in rats.


Cite this article as
: Kırdağ MK, Tuğlu D, Yuvanç E, Kısa Ü, Balcı M, Batislam E, et al. The effect of coenzyme Q and selenium on kidney in rats with partial unilateral ureteral obstruction. Turk J Urol 2018. DOI: 10.5152/tud.2018.22556

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