ISSN 2149-3235 | E-ISSN 2149-3057
Original Article
The influence of metabolic profile of obese men on the severity of erectile dysfunction: are metabolically healthy obese individuals protected?
1 Faculty of Medicine of Universidade do Porto, Alameda Prof. Hernâni Monteiro, Porto, Portugal  
2 Faculty of Biotechnology of Portuguese Catholic University and CBQF/Centro de Biotecnologia e Química Fina, Escola Superior de Biotecnologia, Universidade Católica Portuguesa, Rua Arquiteto Lobão Vital, Porto, Portugal  
3 Department of Urology, Hospital da Luz, Praceta Henrique Moreira 150, 4400-346 Vila Nova de Gaia, Portugal; Instituto de Investigação e Inovação em Saúde (I3S), Rua Alfredo Allen 208, Porto, Portugal  
Turk J Urol 2018; 44: 455-461
DOI: 10.5152/tud.2018.66281
Key Words: Erectile dysfunction; hypogonadism; metabolically healthy obesity; penile duplex Doppler ultrasound
Abstract

Objective: To determine the prevalence of erectile dysfunction (ED) in metabolically healthy obese (MHO) individuals, and to compare ED severity and hypogonadism prevalence in MHO, metabolically unhealthy obese (MUO) and metabolically healthy non-obese individuals.


Material and methods
: ED patients (n=460) were evaluated by standardized protocol, that included clinical evaluation, abridged 5-item version of the International Index of Erectile Function (IIEF-5) questionnaire survey, and Penile Duplex Doppler Ultrasound (PDDU) exam. Patients were classified as obese [body mass index (BMI) ≥30.0 kg/m2] and non-obese (BMI <30.0 kg/m2), and metabolic health status was defined by National Cholesterol Education Program Adult Treatment Panel III (NCEP ATPIII) criteria. Statistical analysis was performed and statistical significance was considered at p-level <0.05.


Results
: The mean age of the subjects was 56.2±10.5 years. MHO was present in 40% of obese individuals (n=37). MUO had lower mean peak systolic velocity (mPSV) compared to MHO (28.1 cm/s vs. 36.9 cm/s; p=0.005), and IIEF-5 scores were also lower in MUO compared to MHO patients (10.2 vs. 13.1; p=0.018). No statistical differences in IIEF-5 score, mPSV and hypogonadism prevalence between MHO and metabolically healthy non-obese (MHNO) patients were observed.


Conclusion
: Our results lead us to conclude that healthy metabolic profile protects obese individuals from severity of ED. The strong association between obesity and ED may be otherwise attributed to metabolic abnormalities present in the obese.


Cite this article as
: Moura A, Tomada I, Tomada N. The influence of metabolic profile of obese men on the severity of erectile dysfunction: are metabolically healthy obese individuals protected? Turk J Urol 2018; 44(6): 455-61.

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