ISSN 2149-3235 | E-ISSN 2149-3057
Original Article
Prognostic significance of tumor budding in muscle invasive urothelial carcinomas of the bladder
1 Department of Pathology, University of Health Sciences, Tepecik Training and Research Hospital, İzmir, Turkey  
2 Department of Pathology, University of Katip Çelebi, Atatürk Training and Research Hospital, İzmir, Turkey  
3 Department of Pathology, Ege University School of Medicine, İzmir, Turkey  
4 Department of Urology, University of Health Sciences, Tepecik Training and Research Hospital, İzmir, Turkey  
5 Department of Urology, Urla State Hospital, İzmir, Turkey  
Turk J Urol ; : -
DOI: 10.5152/tud.2018.58269
Key Words: Bladder, tumor budding, urothelial carcinoma
Abstract

 

Objective: The aim of this study was to evaluate the prognostic significance of tumor budding in muscle invasive urothelial carcinoma of bladder (MIBC).

 

Material and methods: A total of 60 patients who underwent radical cystectomy and cystoprostatectomy for MIBC were included in the study. The correlations between tumor budding, and tumor necrosis, lymphovascular invasion (LVI), perineural invasion (PNI) and histopathological data with distant metastasis were evaluated. The correlation between progression free (PFS) and overall survival (OS) rates and the presence, and grade of tumor budding was investigated.

 

Results: A statistically significant correlation was not seen between tumor budding, necrosis, LVI, and PNI. There was a strong correlation between distant organ metastasis, and presence of tumor necrosis. There was no statistically significant correlation between PFS, OS and tumor budding. A statistically significant relationship was observed between OS and tumor stage, lymph node metastasis, and distant organ metastasis.

 

Conclusion: In our study, statistically significant effect of tumor budding on survival rates in MIBCs was not observed. Also, no significant correlation was observed between tumor budding and tumor necrosis, LVI, and PNI.


Cite this article as: Küçük Ü, Ekmekçi S, Çakır E, Ekin Z, Ergani B, Ekin GR. Prognostic significance of tumor budding in muscle invasive urothelial carcinomas of the bladder. Turk J Urol 2018. DOI: 10.5152/tud.2018.58269.

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