ISSN 2149-3235 | E-ISSN 2149-3057
1 Department of Urology, Erciyes University School of Medicine, Kayseri, Turkey  
2 Department of Medical Genetics, Erciyes University School of Medicine, Kayseri, Turkey  
Turk J Urol ; : -

Abstract

 

Objective: To determine the frequencies and the characteristics of Y chromosome microdeletions in infertile males. 

Material and methods: The records of 1616 infertile males were included in the study. The cases were divided into groups according to the infertility etiology and semen analysis. The frequencies and the characteristics of Y chromosome microdeletions were investigated in groups.


Results: Y chromosome microdeletion was detected in 54 (3.3%) of 1616 cases. Microdeletions in the AZFc region were the most common (48.1%). When the cases were grouped according to infertility causes that could be detected, no Y chromosome microdeletions were detected in some groups (Klinefelter Syndrome, cases with hypogonadotropic hypogonadism, cases with congenital absence of vas deference and cases with 47,XYY karyotype).


Conclusion: Y chromosome microdeletions were detected quite frequently in certain infertility subgroups but not in some. Therefore, detailed evaluation of an infertile man by physical examination, semen analysis, hormonal evaluations and when required, karyotype analysis may predict in which patients Y chromosome microdeletion analysis is necessary and prevent cost increases.

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